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Sugar-Sensing Proteins: A Potential Breakthrough for Sustainable Biofuel

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Saturday, June 15, 2024

Recent research by the Brookhaven National Laboratory explores how plant proteins respond to sugar levels. The study reveals that the sugar proxy molecule’s binding to the KIN10 protein influences plant growth and oil production. This insight could lead to genetic modifications in plants to enhance oil output for biofuels. Credit: SciTechDailyA new study shows how sugar levels influence plant growth and oil production through the protein KIN10, offering the potential for advancements in biofuel production.Proteins function as molecular machines, equipped with flexible components and moving parts. Gaining insight into these movements is crucial for scientists as it helps them understand the role a protein plays in organisms, and it may also guide them in modifying its effects. A team of biochemists from the U.S. Department of Energy’s Brookhaven National Laboratory and the Pacific Northwest National Laboratory have provided new insights into the mechanisms of these molecular machines within plants.In their recent study, published in Science Advances, the researchers focus on how the movements of a specific sugar-sensing protein determine whether plants grow and produce energy-intensive products, such as oil, or if they engage in conservatory measures. This image shows a plant protein known as KIN10 (yellow) that acts as a sensor and a switch to turn oil production off or on depending on whether it interacts with another protein (green). Credit: Brookhaven National LaboratoryMolecular Mechanisms UnveiledJantana Blanford, a Brookhaven Lab biochemist and the study’s lead author, explains, “This paper reveals the detailed mechanism by which plant cells are informed of high sugar availability, influencing biochemical pathways that facilitate plant growth and oil production.”The research expands upon earlier work from Brookhaven’s team that uncovered molecular links between sugar levels and oil production in plants. One potential goal of this research is to identify specific proteins and their components that scientists can engineer to make plants produce more energy-intensive products, such as oil.“Identifying exactly how these molecules and proteins interact, as this new study does, brings us closer to identifying how we might engineer these proteins to increase plant oil production,” said John Shanklin, lead author and chair of Brookhaven Lab’s Biology Department.VIDEOThis animation shows how a flexible loop (orange) on a plant protein known as KIN10 (yellow) allows it to interact with another protein (green) — but only when sugar levels are low. The interaction of the two proteins triggers a cascade of reactions that break down other proteins involved in oil synthesis so the plant can conserve its resources. When sugar levels are high, meaning the plant has abundant resources, a sugar-proxy molecule blocks the loop’s swinging motion. That prevents the protein interaction, which keeps the oil-production pathway open. Credit: Brookhaven National LaboratoryNew Research on Protein InteractionsThe team used a combination of laboratory experiments and computational modeling to zero in on how the molecule that serves as a sugar proxy binds to a “sensor kinase” known as KIN10. KIN10 is the protein that contains the moving parts that determine which biochemical pathways are on or off.The scientists already knew that KIN10 acts as both a sugar sensor and a switch: When sugar levels are low, KIN10 interacts with another protein to set off a cascade of reactions that ultimately shut down oil production and break down energy-rich molecules like oil and starch to make energy that powers the cell. But when sugar levels are high, KIN10’s shut-down function is shut off — meaning plants can grow and make lots of oil and other products with abundant energy.This diagram shows the two pathways KIN10 and an adjacent protein, GRIK1, follow in the low- and high-sugar conditions. Low sugar allows the addition of a phosphate (P) to KIN10, which triggers a phosphorylation cascade that leads to the breakdown of enzymes involved in oil synthesis. This includes degradation of WRI1, the master-switch for oil synthesis. When sugar is abundant, however, a sugar-proxy molecule (T6P) binds to the KIN10 loop to block its interaction with GRIK1. That keeps the oil synthesis pathway open. Credit: Brookhaven National LaboratoryTo identify how the sugar proxy binding to KIN10 flips the switch, Blanford started with the adage “opposites attract.” She identified three positively charged parts of KIN10 that might be attracted to abundant negative charges on the sugar proxy molecule. A laboratory-based process of elimination that involved making variations of KIN10 with modifications to these sites identified the one true binding site.Then the Brookhaven team turned to computational colleagues at PNNL. Marcel Baer and Simone Raugei at PNNL examined at the atomic level how the sugar proxy and KIN10 fit together. “By using multiscale modeling we observed that the protein can exist in multiple conformations but only one of them can effectively bind the sugar proxy,” Baer said.The PNNL simulations identified key amino acids within the protein that control the binding of the sugar. These computational insights were then confirmed experimentally.The combined body of experimental and computational information helped the scientists understand how interaction with the sugar proxy directly affects the downstream action of KIN10.Brookhaven Lab members of the research team: Jantana Blanford, Zhiyang Zhai, Hui Li, Qun Liu, and John Shanklin (not shown: Gongrui Guo). Credit: Brookhaven National LaboratoryThe Role of Flexibility in Protein Function“Additional analyses showed that the entire KIN10 molecule is rigid except for one long flexible loop,” Shanklin said. The models also showed that the loop’s flexibility is what allows KIN10 to interact with an activator protein to trigger the cascade of reactions that ultimately shut down oil production and plant growth.Pacific Northwest National Laboratory co-authors Marcel Baer and Simone Raugei. Credit: Pacific Northwest National LaboratoryWhen sugar levels are low, and little sugar proxy molecule is present, the loop remains flexible, and the shutdown mechanism can operate to reduce plant growth and oil production. That makes sense to conserve precious resources, Shanklin said. However, when sugar levels are high, the sugar proxy binds tightly to KIN10.“The calculations show how this small molecule blocks the loop from swinging around and prevents it from triggering the shutdown cascade,” Blanford said.“We could potentially use our new knowledge to design KIN10 with altered binding strength for the sugar proxy to change the set point at which plants make things like oil and break things down,” Shanklin said. This knowledge could lead to more efficient production of biofuels and other oil-based products.Reference: “Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1” by Jantana Blanford, Zhiyang Zhai, Marcel D. Baer, Gongrui Guo, Hui Liu, Qun Liu, Simone Raugei and John Shanklin, 17 May 2024, Science Advances.DOI: 10.1126/sciadv.adn0895This work was supported by the DOE Office of Science (BES). Computer time was provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory and the Molecular Sciences Computing Facility (MSCF) in the Environmental Molecular Sciences Laboratory at Pacific Northwest National Laboratory. NERSC and MSCF are DOE Office of Science user facilities.

A new study shows how sugar levels influence plant growth and oil production through the protein KIN10, offering the potential for advancements in biofuel production....

A new study shows how sugar levels influence plant growth and oil production through the protein KIN10, offering the potential for advancements in biofuel production.

Proteins function as molecular machines, equipped with flexible components and moving parts. Gaining insight into these movements is crucial for scientists as it helps them understand the role a protein plays in organisms, and it may also guide them in modifying its effects. A team of biochemists from the U.S. Department of Energy’s Brookhaven National Laboratory and the Pacific Northwest National Laboratory have provided new insights into the mechanisms of these molecular machines within plants.

In their recent study, published in Science Advances, the researchers focus on how the movements of a specific sugar-sensing protein determine whether plants grow and produce energy-intensive products, such as oil, or if they engage in conservatory measures.

This image shows a plant protein known as KIN10 (yellow) that acts as a sensor and a switch to turn oil production off or on depending on whether it interacts with another protein (green). Credit: Brookhaven National Laboratory

Molecular Mechanisms Unveiled

Jantana Blanford, a Brookhaven Lab biochemist and the study’s lead author, explains, “This paper reveals the detailed mechanism by which plant cells are informed of high sugar availability, influencing biochemical pathways that facilitate plant growth and oil production.”

The research expands upon earlier work from Brookhaven’s team that uncovered molecular links between sugar levels and oil production in plants. One potential goal of this research is to identify specific proteins and their components that scientists can engineer to make plants produce more energy-intensive products, such as oil.

“Identifying exactly how these molecules and proteins interact, as this new study does, brings us closer to identifying how we might engineer these proteins to increase plant oil production,” said John Shanklin, lead author and chair of Brookhaven Lab’s Biology Department.

VIDEO
This animation shows how a flexible loop (orange) on a plant protein known as KIN10 (yellow) allows it to interact with another protein (green) — but only when sugar levels are low. The interaction of the two proteins triggers a cascade of reactions that break down other proteins involved in oil synthesis so the plant can conserve its resources. When sugar levels are high, meaning the plant has abundant resources, a sugar-proxy molecule blocks the loop’s swinging motion. That prevents the protein interaction, which keeps the oil-production pathway open. Credit: Brookhaven National Laboratory

New Research on Protein Interactions

The team used a combination of laboratory experiments and computational modeling to zero in on how the molecule that serves as a sugar proxy binds to a “sensor kinase” known as KIN10. KIN10 is the protein that contains the moving parts that determine which biochemical pathways are on or off.

The scientists already knew that KIN10 acts as both a sugar sensor and a switch: When sugar levels are low, KIN10 interacts with another protein to set off a cascade of reactions that ultimately shut down oil production and break down energy-rich molecules like oil and starch to make energy that powers the cell. But when sugar levels are high, KIN10’s shut-down function is shut off — meaning plants can grow and make lots of oil and other products with abundant energy.

This diagram shows the two pathways KIN10 and an adjacent protein, GRIK1, follow in the low- and high-sugar conditions. Low sugar allows the addition of a phosphate (P) to KIN10, which triggers a phosphorylation cascade that leads to the breakdown of enzymes involved in oil synthesis. This includes degradation of WRI1, the master-switch for oil synthesis. When sugar is abundant, however, a sugar-proxy molecule (T6P) binds to the KIN10 loop to block its interaction with GRIK1. That keeps the oil synthesis pathway open. Credit: Brookhaven National Laboratory

To identify how the sugar proxy binding to KIN10 flips the switch, Blanford started with the adage “opposites attract.” She identified three positively charged parts of KIN10 that might be attracted to abundant negative charges on the sugar proxy molecule. A laboratory-based process of elimination that involved making variations of KIN10 with modifications to these sites identified the one true binding site.

Then the Brookhaven team turned to computational colleagues at PNNL. Marcel Baer and Simone Raugei at PNNL examined at the atomic level how the sugar proxy and KIN10 fit together. “By using multiscale modeling we observed that the protein can exist in multiple conformations but only one of them can effectively bind the sugar proxy,” Baer said.

The PNNL simulations identified key amino acids within the protein that control the binding of the sugar. These computational insights were then confirmed experimentally.

The combined body of experimental and computational information helped the scientists understand how interaction with the sugar proxy directly affects the downstream action of KIN10.

Brookhaven Lab members of the research team: Jantana Blanford, Zhiyang Zhai, Hui Li, Qun Liu, and John Shanklin (not shown: Gongrui Guo). Credit: Brookhaven National Laboratory

The Role of Flexibility in Protein Function

“Additional analyses showed that the entire KIN10 molecule is rigid except for one long flexible loop,” Shanklin said. The models also showed that the loop’s flexibility is what allows KIN10 to interact with an activator protein to trigger the cascade of reactions that ultimately shut down oil production and plant growth.

Pacific Northwest National Laboratory co-authors Marcel Baer and Simone Raugei. Credit: Pacific Northwest National Laboratory

When sugar levels are low, and little sugar proxy molecule is present, the loop remains flexible, and the shutdown mechanism can operate to reduce plant growth and oil production. That makes sense to conserve precious resources, Shanklin said. However, when sugar levels are high, the sugar proxy binds tightly to KIN10.

“The calculations show how this small molecule blocks the loop from swinging around and prevents it from triggering the shutdown cascade,” Blanford said.

“We could potentially use our new knowledge to design KIN10 with altered binding strength for the sugar proxy to change the set point at which plants make things like oil and break things down,” Shanklin said. This knowledge could lead to more efficient production of biofuels and other oil-based products.

Reference: “Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1” by Jantana Blanford, Zhiyang Zhai, Marcel D. Baer, Gongrui Guo, Hui Liu, Qun Liu, Simone Raugei and John Shanklin, 17 May 2024, Science Advances.
DOI: 10.1126/sciadv.adn0895

This work was supported by the DOE Office of Science (BES). Computer time was provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory and the Molecular Sciences Computing Facility (MSCF) in the Environmental Molecular Sciences Laboratory at Pacific Northwest National Laboratory. NERSC and MSCF are DOE Office of Science user facilities.

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Want to Lower Chemical Exposures in Pregnancy? Quit Nail Polish, Makeup and Hair Dye

By Carole Tanzer Miller HealthDay ReporterTUESDAY, Nov. 19, 2024 (HealthDay News) -- Women who won't leave the house without makeup or a spritz of...

By Carole Tanzer Miller HealthDay ReporterTUESDAY, Nov. 19, 2024 (HealthDay News) -- Women who won't leave the house without makeup or a spritz of hairspray may want to think twice about those habits when they're pregnant or breastfeeding.New research links these and other personal care products, including hair dyes, fragrances, lotions, moisturizers and nail polishes to higher levels of so-called PFAS "forever chemicals" that are harmful to health. Researchers report in the November issue of the journal Environment International that they found significantly higher levels of these synethetic chemicals -- called per- and polyfluoroalkyl substances (PFAS) -- in the blood and breast milk of women who used the products during pregnancy. Because they resist water, oil and heat, PFAS have been used in consumer products and industry since the mid-20th century, researchers said in background notes. Over the years, they have been linked to many health issues, including heart problems, liver disease and cancers.The new study suggests that exposure to PFAS during pregnancy could lead to variety of health issues for babies. They include preterm birth and lower birth weight, as well as neurodevelopmental disorders -- even a poorer response to vaccines, said study author Amber Hall, a postdoctoral research associate at Brown University School of Public Health in Rhode Island."People who are concerned about their exposure to these chemicals during pregnancy or while breastfeeding may benefit from cutting back on personal care products during those times," Hall said in a university news release.Her team analyzed data from a study conducted between 2008 and 2011 of 2,000 pregnant women in 10 Canadian cities. The data included measurements of PFAS levels in the blood at six to 13 weeks of gestation and in breast milk after the birth. Participants self-reported how often they used eight types of products during their first and third trimesters, as well as one to two days postpartum and then again, at two to 10 weeks after giving birth.At all points, higher use of nail care products, fragrances, makeup, hair sprays, gels or dyes was associated with higher levels of PFAS in the blood. Results for third-trimester use and breast-milk concentrations were similar.By way of example, researchers noted that pregnant women who wore makeup every day in their first and third trimesters had higher levels of PFAS than those who didn't. Those who used permanent hair color one or two days after delivery had 16% to 18% higher levels of PFAS in their milk. But Hall cautioned that the study probably underestimated the extent of PFAS exposure. It examined only four types of forever chemicals among thousands deployed in industry and commerce.She conducted the investigation with the director of children's environmental health at Brown, Joseph Braun, who has studied health effect of PFAS chemicals for more than a decade."Not only do studies like these help people assess how their product choices may affect their personal risk, but they can also help us show how these products could have population-level effects," he said. "And that makes the case for product regulation and government action."SOURCE: Brown University, news release, Nov. 12, 2024Copyright © 2024 HealthDay. All rights reserved.

Chemicals

Health

Water

Turning automotive engines into modular chemical plants to make green fuels

The MIT spinout Emvolon is placing its repurposed engines next to methane sources, to generate greener methanol and other chemicals.

Reducing methane emissions is a top priority in the fight against climate change because of its propensity to trap heat in the atmosphere: Methane’s warming effects are 84 times more potent than CO2 over a 20-year timescale.And yet, as the main component of natural gas, methane is also a valuable fuel and a precursor to several important chemicals. The main barrier to using methane emissions to create carbon-negative materials is that human sources of methane gas — landfills, farms, and oil and gas wells — are relatively small and spread out across large areas, while traditional chemical processing facilities are huge and centralized. That makes it prohibitively expensive to capture, transport, and convert methane gas into anything useful. As a result, most companies burn or “flare” their methane at the site where it’s emitted, seeing it as a sunk cost and an environmental liability.The MIT spinout Emvolon is taking a new approach to processing methane by repurposing automotive engines to serve as modular, cost-effective chemical plants. The company’s systems can take methane gas and produce liquid fuels like methanol and ammonia on-site; these fuels can then be used or transported in standard truck containers."We see this as a new way of chemical manufacturing,” Emvolon co-founder and CEO Emmanuel Kasseris SM ’07, PhD ’11 says. “We’re starting with methane because methane is an abundant emission that we can use as a resource. With methane, we can solve two problems at the same time: About 15 percent of global greenhouse gas emissions come from hard-to-abate sectors that need green fuel, like shipping, aviation, heavy heavy-duty trucks, and rail. Then another 15 percent of emissions come from distributed methane emissions like landfills and oil wells.”By using mass-produced engines and eliminating the need to invest in infrastructure like pipelines, the company says it’s making methane conversion economically attractive enough to be adopted at scale. The system can also take green hydrogen produced by intermittent renewables and turn it into ammonia, another fuel that can also be used to decarbonize fertilizers.“In the future, we’re going to need green fuels because you can’t electrify a large ship or plane — you have to use a high-energy-density, low-carbon-footprint, low-cost liquid fuel,” Kasseris says. “The energy resources to produce those green fuels are either distributed, as is the case with methane, or variable, like wind. So, you cannot have a massive plant [producing green fuels] that has its own zip code. 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The work impressed Kasseris enough to bring him back to MIT as a research scientist in 2016.“We worked on that idea in addition to some other projects, and eventually it had reached the point where we decided to license the work from MIT and go full throttle,” Kasseris recalls. “It’s very easy to work with MIT’s Technology Licensing Office when you are an MIT inventor. You can get a low-cost licensing option, and you can do a lot with that, which is important for a new company. 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Many shipping vessels have already converted to run on green methanol in an effort to meet decarbonization goals.This summer, the company also received a grant from the Department of Energy to adapt its process to produce clean liquid fuels from power sources like solar and wind.“We’d like to expand to other chemicals like ammonia, but also other feedstocks, such as biomass and hydrogen from renewable electricity, and we already have promising results in that direction” Kasseris says. “We think we have a good solution for the energy transition and, in the later stages of the transition, for e-manufacturing.”A scalable approachEmvolon has already built a system capable of producing up to six barrels of green methanol a day in its 5,000 square-foot headquarters in Woburn, Massachusetts.“For chemical technologies, people talk about scale up risk, but with an engine, if it works in a single cylinder, we know it will work in a multicylinder engine,” Kasseris says. “It’s just engineering.”Last month, Emvolon announced an agreement with Montauk Renewables to build a commercial-scale demonstration unit next to a Texas landfill that will initially produce up to 15,000 gallons of green methanol a year and later scale up to 2.5 million gallons. 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The US no longer supports capping plastic production in UN treaty

Environmental advocates understand the announcement as a reversal, calling it “absolutely devastating.”

The Biden administration has backtracked from supporting a cap on plastic production as part of the United Nations’ global plastics treaty. According to representatives from five environmental organizations, White House staffers told representatives of advocacy groups in a closed-door meeting last week that they did not see mandatory production caps as a viable “landing zone” for INC-5, the name for the fifth and final round of plastics treaty negotiations set to take place later this month in Busan, South Korea. Instead, the staffers reportedly said United States delegates would support a “flexible” approach in which countries set their own voluntary targets for reducing plastic production. This represents a reversal of what the same groups were told at a similar briefing held in August, when Biden administration representatives raised hopes that the U.S. would join countries like Norway, Peru, and the United Kingdom in supporting limits on plastic production. Following the August meeting, Reuters reported that the U.S. “will support a global treaty calling for a reduction in how much new plastic is produced each year,” and the Biden administration confirmed that Reuters’ reporting was “accurate.” After the more recent briefing, a spokesperson for the White House Council on Environmental Quality told Grist that, while U.S. negotiators have endorsed the idea of a “‘North Star’ aspirational global goal” to reduce plastic production, they “do not see this as a production cap and do not support such a cap.” “We believe there are different paths available for achieving reductions in plastic production and consumption,” the spokesperson said. “We will be flexible going into INC-5 on how to achieve that and are optimistic that we can prevail with a strong instrument that sends these market signals for change.” Jo Banner, co-founder and co-director of The Descendants Project, a nonprofit advocating for fenceline communities in Louisiana’s “Cancer Alley,” said the announcement was a “jolt.” “I thought we were on the same page in terms of capping plastic and reducing production,” she said. “But it was clear that we just weren’t.” Frankie Orona, executive director of the nonprofit Society of Native Nations, which advocates for environmental justice and the preservation of Indigenous cultures, described the news as “absolutely devastating.” He added, “Two hours in that meeting felt like it was taking two days of my life.” Delegates follow the day’s proceedings at the third round of negotiations over a global plastics treaty in Nairobi, Kenya. James Wakibia / SOPA Images / LightRocket via Getty Images The situation speaks to a central conflict that has emerged from talks over the treaty, which the U.N. agreed to negotiate two years ago to “end plastic pollution.” Delegates haven’t agreed on whether the pact should focus on managing plastic waste — through things like ocean cleanups and higher recycling rates — or on tamping down the growing rate of plastic production. Nearly 70 countries, along with scientists and environmental groups, support the latter. They say it’s futile to mop up plastic litter while more and more of it keeps getting made. But a vocal contingent of oil-exporting countries has pushed for a lower-ambition treaty, using a consensus-based voting norm to slow-walk the negotiations. Besides leaving out production limits, those countries also want the treaty to allow for voluntary national targets, rather than binding global rules. Exactly which policies the U.S. will now support isn’t entirely clear. While the White House spokesperson told Grist that it wants to ensure the treaty “addresses … the supply of primary plastic polymers,” this could mean a whole host of things, including a tax on plastic production or bans on individual plastic products. These kinds of so-called market instruments could drive down demand for more plastic, but with far less certainty than a quantitative production limit. Bjorn Beeler, executive director of the nonprofit International Pollutants Elimination Network, noted that the U.S. could technically “address” the supply of plastics by reducing the industry’s projected growth rates — which would still allow the amount of manufactured plastic to continue increasing every year. “What the U.S. has said is extremely vague,” he said. “They have not been a leading actor to move the treaty into something meaningful.” To the extent that the White House’s latest announcement was a clarification and not an outright reversal — as staffers reportedly insisted was the case — Banner said the Biden administration should have made their position clearer months ago, right after the August meeting. “In August, we were definitely saying ‘capping,’ and it was never corrected,” she said. “If there was a misunderstanding, then it should have been corrected a long time ago.” Another apparent change in the U.S.’s strategy is on chemicals used in plastics. Back in August, the White House confirmed via Reuters’ reporting that it supported creating lists of plastic-related chemicals to be banned or restricted. Now, negotiators will back lists that include plastic products containing those chemicals. Environmental groups see this approach as less effective, since there are so many kinds of plastic products and because product manufacturers do not always have complete information about the chemicals used by their suppliers. Read Next Plastic chemicals are inescapable — and they’re messing with our hormones Joseph Winters Orona said focusing on products would push the conversation downstream, away from petrochemical refineries and plastics manufacturing facilities that disproportionately pollute poor communities of color. “It’s so dismissive, it’s so disrespectful,” he said. “It just made you want to grab a pillow and scream into the pillow and shed a few tears for your community.” At the next round of treaty talks, environmental groups told Grist that the U.S. should “step aside.” Given the high likelihood that the incoming Trump administration will not support the treaty and that the Republican-controlled Senate will not ratify it, some advocates would like to see the high-ambition countries focus less on winning over U.S. support and more on advancing the most ambitious version of the treaty possible. “We hope that the rest of the world moves on,” said a spokesperson for the nonprofit Break Free From Plastic, vesting hope in the EU, small island developing states, and a coalition of African countries, among others. Viola Waghiyi, environmental health and justice program director for the nonprofit Alaska Community Action on Toxics, is a tribal citizen of the Native Village of Savoonga, on the island of Sivuqaq off the state’s western coast. She connected a weak plastics treaty to the direct impacts her island community is facing, including climate change (to which plastics production contributes), microplastic pollution in the Arctic Ocean that affects its marine life, and atmospheric dynamics that dump hazardous plastic chemicals in the far northern hemisphere. The U.S. “should be making sure that measures are in place to protect the voices of the most vulnerable,” she said, including Indigenous peoples, workers, waste pickers, and future generations. As a Native grandmother, she specifically raised concerns about endocrine-disrupting plastic chemicals that could affect children’s neurological development. “How can we pass on our language, our creation stories, our songs and dances, our traditions and cultures, if our children can’t learn?” This story was originally published by Grist with the headline The US no longer supports capping plastic production in UN treaty on Nov 18, 2024.

Chemicals

Climate

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Yorkshire town may bring first ‘forever chemicals’ legal case in UK

Residents claim contamination from Angus Fire factory has left them trapped and unable to sell their homesResidents in the UK town with the country’s highest identified concentration of “forever chemicals” have instructed lawyers to investigate the possibility of a first-of-its-kind legal claim against the firefighting foam manufacturer located in the centre of Bentham.In May this year, an investigation by the Ends Report and the Guardian revealed that the rural North Yorkshire town is the most PFAS-polluted place known to exist in the UK. The town is home to the firefighting foam manufacturer Angus Fire. Continue reading...

Residents in the UK town with the country’s highest identified concentration of “forever chemicals” have instructed lawyers to investigate the possibility of a first-of-its-kind legal claim against the firefighting foam manufacturer located in the centre of Bentham.In May this year, an investigation by the Ends Report and the Guardian revealed that the rural North Yorkshire town is the most PFAS-polluted place known to exist in the UK. The town is home to the firefighting foam manufacturer Angus Fire.PFAS, short for per- and polyfluoroalkyl substances and commonly known as “forever chemicals” owing to their persistence in the environment, are a family of about 10,000 chemicals that have been linked to a wide range of serious illnesses, including certain cancers. They are used in many consumer products, from frying pans to waterproof coats, but one of their most common uses is in firefighting foams.The Law firm Leigh Day has informed Angus Fire that, acting on behalf of residents, it has been instructed to investigate a case against the firm as a result of “alleged PFAS pollution in Bentham”.A spokesperson for Angus Fire said: “We have been advised by Leigh Day that it is under instruction to investigate a potential claim on behalf of one residency. We have not received notice of any legal action.”In the past 25 years, nearly 10,000 court cases have been filed in the US alleging harm from PFAS exposure. Some of these cases have already resulted in multi-billion dollar settlements. The case against Angus Fire would be be the first ever PFAS-related legal case in the UK.Charlotte Armstrong, a senior associate solicitor at Leigh Day, said: “Angus Fire state that they no longer manufacture or test any PFAS-containing foam products in Bentham, but that doesn’t help the people of Bentham. PFAS are ‘forever chemicals’, and unfortunately that means that the chemical pollution in the area is anything but a historic issue. Our clients and the wider community in Bentham are entitled to fully understand the extent of PFAS pollution in their community, so that those allegedly responsible can be held to account in terms of financial compensation and remediation.”After the initial investigation, Bentham town council asked Angus Fire to test the environment on Duke Street – a narrow residential road next to the factory – for PFAS.The test results, which were made available in October, revealed that soil adjacent to gardens on Duke Street was contaminated with elevated levels of PFAS. The land is owned by Angus Fire and is made available for use by residents, who use it to grow food. Residents were advised by Angus Fire to wash and peel vegetables grown on the land, to clean their homes of dust regularly, and to remove shoes before entering their homes.Residents of Duke Street have said that since finding out about the contamination they felt “trapped”.“At any point of buying a house, you would want the option to sell it, depending on what you want to do in your life,” said one person, who asked to remain anonymous. “At the moment, that would be a significant challenge. And with the uncertainty over how long it will take to remediate the land, we are essentially trapped in this situation.”Angus Fire has offered residents on Duke Street a series of financial “goodwill gestures”.A spokesperson for Angus Fire said it had “presented a number of options to residents whose properties border the legacy foam manufacturing and testing areas, which we believe could offer a constructive way forward and which also underscores our commitment to addressing the situation responsibly.“We recognise the concerns about potential environmental impacts from historic operations at our facility and regret the inconvenience and worry that this has caused.”skip past newsletter promotionThe planet's most important stories. Get all the week's environment news - the good, the bad and the essentialPrivacy Notice: Newsletters may contain info about charities, online ads, and content funded by outside parties. For more information see our Privacy Policy. We use Google reCaptcha to protect our website and the Google Privacy Policy and Terms of Service apply.after newsletter promotionDuke Street residents have expressed concern about the risk of the contamination to their health.Dr Anna Watson, the director of policy and advocacy at the Chem Trust charity, said that while it was welcome that Angus Fire was “admitting responsibility for the irreversible PFAS pollution near their site in Bentham”, it was “heartbreaking to think of people being uprooted from their community, as well as having to deal with the anxiety of potential long-term health impacts from these toxic chemicals”.“The UK government needs to take urgent action to ban the use and manufacture of these chemicals as a group and be at the forefront of a global PFAS-free economy,” she said.Residents said they had had no correspondence with local or government officials over the contamination.An Environment Agency spokesperson said: “We are working with North Yorkshire council and looking into historic PFAS contamination from the Angus Fire site. Our primary focus is to assess the risk to the environment and provide support to our partners on risk to residents.”North Yorkshire council’s assistant director for regulatory services, Callum McKeon, said: “We continue to work with partner agencies to assess historic PFAS contamination from the Angus Fire site at Bentham. Our key priority is to identify and address the risk to residents and continue to support our partner agencies with their ongoing investigations.”The Angus Fire spokesperson said: “Angus continues to work closely with independent industry-leading environmental consultants and in cooperation with our UK regulator, the Environment Agency, to better characterise the Bentham site and surrounding areas. These further investigations will help us better understand the extent of any PFAS contamination and assist in determining the remediation required.”

Chemicals

Food

Health

New report: Dow Freeport chemical plant leads nation in wastewater polluting

The Dow Freeport petrochemical plant in Brazoria County was found to be the top polluter of three toxic chemicals, causing downstream health risks to nearby communities of color and low-income households.

Michael StravatoThe Dow chemical plant along the Brazos River in Freeport, Texas.The Dow petrochemical plant in Freeport, Texas was found to be the worst wastewater polluter in the nation, according to a new report. That's one of the findings of the Environmental Integrity Project's (EIP) latest study entitled, "Plastic's Toxic River," which was released Thursday afternoon. The report, which looks into data from 2021 to 2023, found that dozens of petrochemical plants — factories that use oil and gas to make plastics, industrial chemicals and pesticides — have been breaking federal regulations without substantial, if any, repercussions. Among the 70 petrochemical plants the EIP reported on, 58 were found to have violated at least one wastewater regulation. Only eight plants have been penalized, with the average fine being $266. Krisen Schlemmer, a senior legal director at Bayou City Waterkeeper, a Houston-based environmental protection nonprofit, emphasized in a webinar that when it comes to violating wastewater regulations, "some of the worst actors are here in our backyard in Texas." Among the plants that have violated the Clean Waters Act, 28 are in Texas, leaving only two plants in the state that have not broken federal wastewater regulations. Local environmental experts and the report's authors point to the Environmental Protection Agency's lax regulations for why plants have continued to dump dangerous — and at high amounts lethal — chemicals into waterways. Jen Duggan, the EIP’s executive director, said it’s communities of color and low-income households that are the most at risk. "The unchecked pollution from these plants hurts peoples' livelihoods and quality of life, it puts our health at risk," Duggan said. "It puts our health at risk, and it shifts the cost of cleaning up this pollution to communities instead of the companies who are creating it.” The Dow plant in Brazoria County was the report's top wastewater polluter of three toxic chemicals: dioxin, nitrogen and phosphorus, and dioxin. Dioxin is a potent and toxic chemical that has been linked to cancer, reproductive and developmental problems, hormone imbalances and weakened immune systems. Just one drop of dioxin is enough to contaminate 44 swimming pools, according to the EPA. Yet, there aren't federal limits to the amount of dioxins plastics and chemical plants can release into waterways. The Dow Freeport plant released more than 800 grams of dioxins into the Brazos River in 2022. Additionally, according to the report, in 2023 it released more than 3.3 million pounds of nitrogen and nearly 700,000 pounds of phosphorus into the river. Schlemmer said both chemicals "degrade water quality, making it difficult for life to survive in the water. Yet, these are exactly the things that the Dows Freeport facility was found to have discharged into the Brazos River, which is upstream from popular fishing spots as well as a surfside beach." To encourage tougher regulations over petrochemical plants, the report's authors made five recommendations to protect communities and wildlife: Require the use of modern wastewater pollution tracking technology Prohibit dumping plastic pellets into waterways Update and improve monitoring requirements in permit applications and permits Increase enforcement of Clean Water Act permit violations and impose penalties Improve permit transparency and recordkeeping

Chemicals

Health

Water

Suggested Viewing

Lead in the Land

Lead in the Land is a documentary focusing on the harsh reality and far-reaching effects of lead poisoning, an invisible and insidious threat afflicting thousands of children in the United States. The film sheds light on the circumstances around lead poisoning, examining its causes, effects and potential solutions.

Chemicals

Social Justice

Health

Sprayed

An exploration of what happens when whole communities get exposed to toxins: Naled sprayed on Miami residents to fight Zika virus, Agent Orange sprayed on the Vietcong, and release of GMO mosquitoes in Brazil with pyriproxyfen added to drinking water to fight dengue. What are the results for nature and humanity? We meet Agent Orange survivors at Vietnamese detoxification and rehabilitation centers, parents of babies born with microcephaly from Zika virus, and Florida residents dealing with efforts to kill mosquitoes carrying Zika virus. Perspectives of doctors, scientists, and politicians are balanced with voices of ordinary citizens and victims to explore concerns about the potential impact on current and future generations.

Chemicals

Health

Science

We Trees

Ever wonder what trees think of us now that we have created a climate disaster? This 2-minute film answers that question. As Bill McKibben recently tweeted about the film, “Who speaks for trees? In this short and elegant video, the trees themselves.” It has been screened at Green Fest (Serbia), The Colorado Environmental Film Festival, The Wildlife Conservation Film Festival and Winner of Merit at the Nature Without Borders Film Festival.

Forests

Chemicals

Climate

Toxic Business

A documentary on the profits international chemical companies are gaining in Africa at cost of the health of small-scaled-farmers and consumers.International chemical companies sell high toxic agro-chemicals in Kenya, which are banned since long in Europe. They are banned because their ingredients cause cancer and have a major negative impact on the nature and environment. Anyhow – in developing countries like Kenya those toxic chemicals are sold without any regulations through small agro-shops all over the country. The small scaled farmers do believe in the promises of better and safer harvest those companies give. Today, the use of pesticides even inside the villages is already a daily business. Furthermore many of them already depend on hybrid seeds, old and resistant seeds supplants. Most of the consumers do not have the knowledge, how dangerous those agro-chemicals are: the WHO announced that annually 346.000 people die, caused by accidentally poisoning with those chemicals, 2/3 of them within developing countries.In the face of world food, industry is trying to push its way into the markets. On the contrary, statistics and alternative farming methods in East Africa show that it no longer needs chemicals and hybrid seeds to feed the world, but a general rethinking.

Agriculture

Chemicals

Business

Bag It

Bag It examines our society’s use and abuse of plastic. The theme of the film focuses on plastic as it relates to our society’s throw away mentality, our culture of convenience, and our over consumption of throwaway products and packaging—things that we use one time and then, without another thought, we throw them away. Bag It offers a candid view of the disturbing realities of our culture. And, it suggests concrete solutions to our plastic addiction. The film will raise public awareness on the many issues related to plastic and inspire change, both on the individual level and on the public policy level.

Chemicals

Waste

Culture

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