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Nearsightedness Has Become a Global Health Issue

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Tuesday, October 1, 2024

In 350 B.C.E. Aristotle noted that some people went about their days with what he called “short sight.” People with this condition, he found, would habitually narrow their eyelids to focus their vision—an observation widely credited as the first attempt at defining nearsightedness, or myopia. More than two millennia later, health officials are paying new attention to this old condition for a startling reason: myopia has reached epidemic levels worldwide.Myopia’s prevalence has dramatically increased in recent decades, now affecting as much as 88 percent of the population in some Asian countries. Although it seems most acute in Asian cities, myopia’s growing prevalence is by no means an exclusively regional trend. By 2050, according to one estimate, five billion people—half the world’s population—will be nearsighted. The U.S., which has been less diligent than some other countries in tracking myopia cases, saw a jump in prevalence from 25 percent of people aged 12 to 54 in the early 1970s to 42 percent in the early 2000s, according to the last major national survey of the condition.These statistics matter because myopia is a leading cause of visual impairment, and it can precipitate serious diagnoses that range from detached retinas to glaucoma.On supporting science journalismIf you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.A search is now underway for tangible measures to stem this rising tide. An expert panel from the National Academies of Sciences, Engineering and Medicine (NASEM) released a report in September entitled Myopia: Causes, Prevention, and Treatment of an Increasingly Common Disease. It lays out a series of recommendations, one of which calls for the Centers for Medicare & Medicaid Services to reclassify myopia as a disease that necessitates a medical diagnosis—a step that would encourage federal and state agencies, along with professional associations, to devote resources to reversing the situation. Notably, the committee also recommended that children spend one to two hours outdoors each day.Terri L. Young, co-chair of the NASEM committee that produced the report and chair of the department of ophthalmology and visual sciences at the University of Wisconsin–Madison, talked with Scientific American about the implications of the myopia epidemic for people with myopia and policymakers.[An edited transcript of the interview follows.]I’d like to begin with the most basic of basics. Could you define what myopia, or nearsightedness, is?I’ll start off with what a person with myopia experiences. Myopia is a condition in which an individual sees an object up close clearly but cannot see it clearly at a distance without optical correction. They have natural blurred vision at a distance.Optically, there is a detailed definition that involves the very basics of how we see. Scattered light rays that enter the eye pass through multiple ocular components that reduce the scatter to focus the rays onto the retina, which converts the light into an electrical signal that is transferred through the optic nerve. The optic nerve is similar to a telephone cable that connects the eye to the occipital cortex at the very back of the brain, where what is viewed is then processed and interpreted.The focus of those wavelengths that enter the eye and travel through all its optical components needs to coincide on the retina. In the case of nearsightedness, or myopia, the focus of the light occurs in front of the retina.Myopia seems to be getting more attention lately, both in the U.S. and internationally. Why is that?Myopia prevalence rates are at epidemic levels, especially in urban Asian communities, where in recent times upward of 80 to 90 percent of young individuals have developed myopia. There are large, government-sponsored myopia research institutes in many parts of Asia, including Taiwan, Singapore, China, Hong Kong and Japan.Take Singapore, for example. All young men there are required to perform [two years] of military service after completing high school. Many of these military conscripts, and in particular the ones who are being prepared to go into battle or fly fighter planes, often need glasses or other corrective means for their myopia to fulfill those functions, causing concern for national security.And what about in the U.S.?It’s now certainly an issue in the U.S. as well. Research on myopia is conducted primarily in ophthalmologic and optometric training and research academic programs. But it hasn’t garnered, for whatever reasons, the same sense of urgency and funding as is the case for other parts of the world.In the U.S., we don’t have good prevalence data for myopia and other refractive errors, such as astigmatism and hyperopia [farsightedness]. Health care in this country is so varied in terms of everything from access to dissemination of vision care; because we don’t have a nationalized health system, we also don’t have a national database to provide standardized tracking and reporting.Aren’t there already simple ways to deal with myopia, such as getting a new prescription for glasses? Why is it perceived as becoming a global health problem?Myopia correction is not just an inconvenience of glasses or contact lenses. It predisposes a person to other eye conditions that can lead to blindness. Higher degrees of myopia are associated with eye conditions: premature cataracts, glaucoma, retinal tears and detachments and myopic macular degeneration.What’s happened in Asian communities is that the baseline level of refraction, the deflection of wavelengths as they pass through the eye, is trending toward nearsightedness. This shift is reflected in more individuals with high-grade myopia, with its increased ocular risks, as I described earlier. So instead of that group reflecting 3 to 5 percent of myopic individuals, it’s risen to 10 percent or more.Access to quality vision care, with proper and standardized dissemination for all children, is a major issue in [the U.S.] There are many children who don’t have steady access to care and the opportunity for continued changes in spectacle correction as they grow. If they can’t see, they can’t learn. If they don’t learn, they may get discouraged. If they get discouraged, they tend to act out or to not perform well in school—which has lifelong educational, vocational and economic impacts.Is there some idea why this myopia epidemic is happening?Nowadays, children are indoors more often, and they’re not getting as much outdoor play. Outdoor light enables the visual system to process a variety of spectral wavelengths of light for a certain duration of time, and that affects normal eye development and growth. Our report reaffirms what has been in the scientific literature for more than 15 years: increased childhood outdoor time appears to be protective for myopia onset and development.In urban Asia, education is highly regarded, and children undergo indoor schooling for relatively more hours per day—routinely with additional tutorial sessions on evenings and weekends. In Singapore, for example, there are fewer green spaces, and living situations are generally more vertical because of limited land mass. There are fewer nonclassroom hours and places for children to go outside to view the horizon for extended periods of time. That’s becoming more of the case in the urban U.S. as well.What does being outside do to promote healthy eyes?There are different and varied light wavelengths that enter the eye from outdoor versus indoor exposures. And there are differences in luminance—higher-intensity versus lower-intensity light levels. In the report, there is a lengthy discussion on what is called the “visual diet”—the environmental factors affecting the myopic eye—and there is a consensus that more research is needed.What about the role of electronic devices in promoting myopia?That’s certainly a trend that has exponentially grown in activity and use in our younger generations. I am a pediatric ophthalmologist. I see two- or three-year old children in my clinic who are comfortably playing with cell phones. This close-up activity is generally indoors. The limited research findings regarding electronic device impact on myopia development are inconclusive, however. Reflected in our report, studies could not support unequivocal evidence that using digital devices, especially electronic small devices, is an influencer for this shift toward myopia.What measures have countries implemented to try preventing or correcting myopia in young people?The Singapore Ministry of Health instituted outdoor playtime or recess during school hours. There are now programs in China and in Taiwan where classroom settings have been altered with the use of glass walls or colored light bulb use to increase outdoor daylight exposure. Children are undergoing treatment with atropine eye drops, which in some reports diminishes the shift toward myopia over time in the school-age years. The effect of the drops is not curative, however, and there are concerns regarding unknown long-term effects because we don’t quite understand the specific biochemical actions of atropine. Diagnosed children are also prescribed multifocal contact lenses or eyeglasses [progressive lenses that have different prescription zones to correct vision at different distances].One of the main findings of the report that you co-chaired is the recommendation that myopia be classified as a disease. Can you explain why the consensus of the panel felt that was important?The issue needs escalation to a recognized disease category to underscore its short- and long-term visual health consequences, and to attract attention and funding dollars on multiple and varied fronts for effective screening, treatment, prevention and research study.It takes a multipronged team to elevate this issue. That groundswell would have to come from parents, educators and educator societies, local to national health care systems, local to national policymakers, public health experts, researchers, funding agencies, insurance companies, etcetera. All [of these groups] need to recognize that continuous vision screening starting in early childhood is important. In addition to implementation, the data from those screening visits need to be collated for national database entry for improved monitoring in this country.What do you think should be the main takeaway from this report?In this country, if we elevate this condition to be considered a disease and recognize its impact on our children and ultimately on our future workforce, that would be monumental.

Myopia is projected to affect half of the world’s population by 2050. A new report says it needs to be countered by classifying it as a disease and upping children’s outdoor time

In 350 B.C.E. Aristotle noted that some people went about their days with what he called “short sight.” People with this condition, he found, would habitually narrow their eyelids to focus their vision—an observation widely credited as the first attempt at defining nearsightedness, or myopia. More than two millennia later, health officials are paying new attention to this old condition for a startling reason: myopia has reached epidemic levels worldwide.

Myopia’s prevalence has dramatically increased in recent decades, now affecting as much as 88 percent of the population in some Asian countries. Although it seems most acute in Asian cities, myopia’s growing prevalence is by no means an exclusively regional trend. By 2050, according to one estimate, five billion people—half the world’s population—will be nearsighted. The U.S., which has been less diligent than some other countries in tracking myopia cases, saw a jump in prevalence from 25 percent of people aged 12 to 54 in the early 1970s to 42 percent in the early 2000s, according to the last major national survey of the condition.

These statistics matter because myopia is a leading cause of visual impairment, and it can precipitate serious diagnoses that range from detached retinas to glaucoma.


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


A search is now underway for tangible measures to stem this rising tide. An expert panel from the National Academies of Sciences, Engineering and Medicine (NASEM) released a report in September entitled Myopia: Causes, Prevention, and Treatment of an Increasingly Common Disease. It lays out a series of recommendations, one of which calls for the Centers for Medicare & Medicaid Services to reclassify myopia as a disease that necessitates a medical diagnosis—a step that would encourage federal and state agencies, along with professional associations, to devote resources to reversing the situation. Notably, the committee also recommended that children spend one to two hours outdoors each day.

Terri L. Young, co-chair of the NASEM committee that produced the report and chair of the department of ophthalmology and visual sciences at the University of Wisconsin–Madison, talked with Scientific American about the implications of the myopia epidemic for people with myopia and policymakers.

[An edited transcript of the interview follows.]

I’d like to begin with the most basic of basics. Could you define what myopia, or nearsightedness, is?

I’ll start off with what a person with myopia experiences. Myopia is a condition in which an individual sees an object up close clearly but cannot see it clearly at a distance without optical correction. They have natural blurred vision at a distance.

Optically, there is a detailed definition that involves the very basics of how we see. Scattered light rays that enter the eye pass through multiple ocular components that reduce the scatter to focus the rays onto the retina, which converts the light into an electrical signal that is transferred through the optic nerve. The optic nerve is similar to a telephone cable that connects the eye to the occipital cortex at the very back of the brain, where what is viewed is then processed and interpreted.

The focus of those wavelengths that enter the eye and travel through all its optical components needs to coincide on the retina. In the case of nearsightedness, or myopia, the focus of the light occurs in front of the retina.

Myopia seems to be getting more attention lately, both in the U.S. and internationally. Why is that?

Myopia prevalence rates are at epidemic levels, especially in urban Asian communities, where in recent times upward of 80 to 90 percent of young individuals have developed myopia. There are large, government-sponsored myopia research institutes in many parts of Asia, including Taiwan, Singapore, China, Hong Kong and Japan.

Take Singapore, for example. All young men there are required to perform [two years] of military service after completing high school. Many of these military conscripts, and in particular the ones who are being prepared to go into battle or fly fighter planes, often need glasses or other corrective means for their myopia to fulfill those functions, causing concern for national security.

And what about in the U.S.?

It’s now certainly an issue in the U.S. as well. Research on myopia is conducted primarily in ophthalmologic and optometric training and research academic programs. But it hasn’t garnered, for whatever reasons, the same sense of urgency and funding as is the case for other parts of the world.

In the U.S., we don’t have good prevalence data for myopia and other refractive errors, such as astigmatism and hyperopia [farsightedness]. Health care in this country is so varied in terms of everything from access to dissemination of vision care; because we don’t have a nationalized health system, we also don’t have a national database to provide standardized tracking and reporting.

Aren’t there already simple ways to deal with myopia, such as getting a new prescription for glasses? Why is it perceived as becoming a global health problem?

Myopia correction is not just an inconvenience of glasses or contact lenses. It predisposes a person to other eye conditions that can lead to blindness. Higher degrees of myopia are associated with eye conditions: premature cataracts, glaucoma, retinal tears and detachments and myopic macular degeneration.

What’s happened in Asian communities is that the baseline level of refraction, the deflection of wavelengths as they pass through the eye, is trending toward nearsightedness. This shift is reflected in more individuals with high-grade myopia, with its increased ocular risks, as I described earlier. So instead of that group reflecting 3 to 5 percent of myopic individuals, it’s risen to 10 percent or more.

Access to quality vision care, with proper and standardized dissemination for all children, is a major issue in [the U.S.] There are many children who don’t have steady access to care and the opportunity for continued changes in spectacle correction as they grow. If they can’t see, they can’t learn. If they don’t learn, they may get discouraged. If they get discouraged, they tend to act out or to not perform well in school—which has lifelong educational, vocational and economic impacts.

Is there some idea why this myopia epidemic is happening?

Nowadays, children are indoors more often, and they’re not getting as much outdoor play. Outdoor light enables the visual system to process a variety of spectral wavelengths of light for a certain duration of time, and that affects normal eye development and growth. Our report reaffirms what has been in the scientific literature for more than 15 years: increased childhood outdoor time appears to be protective for myopia onset and development.

In urban Asia, education is highly regarded, and children undergo indoor schooling for relatively more hours per day—routinely with additional tutorial sessions on evenings and weekends. In Singapore, for example, there are fewer green spaces, and living situations are generally more vertical because of limited land mass. There are fewer nonclassroom hours and places for children to go outside to view the horizon for extended periods of time. That’s becoming more of the case in the urban U.S. as well.

What does being outside do to promote healthy eyes?

There are different and varied light wavelengths that enter the eye from outdoor versus indoor exposures. And there are differences in luminance—higher-intensity versus lower-intensity light levels. In the report, there is a lengthy discussion on what is called the “visual diet”—the environmental factors affecting the myopic eye—and there is a consensus that more research is needed.

What about the role of electronic devices in promoting myopia?

That’s certainly a trend that has exponentially grown in activity and use in our younger generations. I am a pediatric ophthalmologist. I see two- or three-year old children in my clinic who are comfortably playing with cell phones. This close-up activity is generally indoors. The limited research findings regarding electronic device impact on myopia development are inconclusive, however. Reflected in our report, studies could not support unequivocal evidence that using digital devices, especially electronic small devices, is an influencer for this shift toward myopia.

What measures have countries implemented to try preventing or correcting myopia in young people?

The Singapore Ministry of Health instituted outdoor playtime or recess during school hours. There are now programs in China and in Taiwan where classroom settings have been altered with the use of glass walls or colored light bulb use to increase outdoor daylight exposure. Children are undergoing treatment with atropine eye drops, which in some reports diminishes the shift toward myopia over time in the school-age years. The effect of the drops is not curative, however, and there are concerns regarding unknown long-term effects because we don’t quite understand the specific biochemical actions of atropine. Diagnosed children are also prescribed multifocal contact lenses or eyeglasses [progressive lenses that have different prescription zones to correct vision at different distances].

One of the main findings of the report that you co-chaired is the recommendation that myopia be classified as a disease. Can you explain why the consensus of the panel felt that was important?

The issue needs escalation to a recognized disease category to underscore its short- and long-term visual health consequences, and to attract attention and funding dollars on multiple and varied fronts for effective screening, treatment, prevention and research study.

It takes a multipronged team to elevate this issue. That groundswell would have to come from parents, educators and educator societies, local to national health care systems, local to national policymakers, public health experts, researchers, funding agencies, insurance companies, etcetera. All [of these groups] need to recognize that continuous vision screening starting in early childhood is important. In addition to implementation, the data from those screening visits need to be collated for national database entry for improved monitoring in this country.

What do you think should be the main takeaway from this report?

In this country, if we elevate this condition to be considered a disease and recognize its impact on our children and ultimately on our future workforce, that would be monumental.

Read the full story here.
Photos courtesy of

Tree Rings May Reveal Hidden Clues About Water History

By I. Edwards HealthDay ReporterTUESDAY, Dec. 23, 2025 (HealthDay News) — Trees don’t just clean the air, they also keep a quiet record of the...

TUESDAY, Dec. 23, 2025 (HealthDay News) — Trees don’t just clean the air, they also keep a quiet record of the past.New research suggests that tree rings may help scientists uncover missing pieces of environmental history, especially when it comes to water in the midwest. By studying how different tree species respond to wet and dry conditions, researchers say they can better understand how watersheds have changed over time, and how they may change in the future.Watersheds are areas of land that drain water into nearby streams, rivers and lakes. Healthy watersheds help protect drinking water, support wildlife and keep ecosystems balanced, according to the U.S. Environmental Protection Agency. But climate change can put a big strain on these systems, especially when historical data is limited.“One human lifespan is not going to show us the big picture,” study leader Alessandra Bertucci, a graduate student at Ohio State University in Columbus, said in a news release."So using trees to address these gaps of understanding is really important for managing water resources, even in intensively managed watersheds," Bertucci added.Trees typically grow a new ring each year and the size and density of those rings can reflect weather conditions such as droughts, floods and long periods of rain. But not all trees record these events the same way. That’s why the research team found that using multiple tree species gives a clearer picture than relying on just one.The study focused on riparian trees, which grow near rivers and streams in the Midwest. Researchers found that many of these trees are especially good at recording past wet and dry periods, making them useful for understanding regional water patterns.The work was recently presented at a meeting of the American Geophysical Union in New Orleans.To gather their data, researchers collected tree core samples from areas where long-term watershed records are scarce, including Ohio’s Old Woman Creek State Nature Preserve near Lake Erie. They studied three common tree species and compared ring width and density with recorded climate data.Because much of the Midwest is heavily farmed, accurate water data is critical. Bertucci said limited historical records can lead to poor estimates of past floods or droughts, which may affect decisions about water use and conservation.With the updated tree ring data, the team hopes to build models that can help predict how weather patterns and water flow may change in the coming decades.“If we can round out that historical data and understand what to expect, we can better plan for how to manage our water resources in the future,” Bertucci said.Researchers plan to expand their work by sampling more tree species and studying additional watersheds. The findings could help farmers, water managers and communities make smarter decisions about water conservation.“Water is life,” Bertucci said. “We literally cannot live without it, so it’s important to protect and make sure that we are taking care of it, because that is our lifeline.”Research presented at meetings should be considered preliminary, until published in a peer-reviewed journal.SOURCE: Ohio State University, news release, Dec. 19, 2025Copyright © 2025 HealthDay. All rights reserved.

How Bay Area cops changed their approach to mental health calls

A mental health clinician with a bullet-proof vest is helping change the way a Bay Area city responds to some of its emergency calls. That’s what CalMatters’ Cayla Mihalovich found when she visited the San Mateo Police Department earlier this month to check out a new approach for mental health calls.  The city was one […]

Briana Fair, San Mateo Police Department’s mental health clinician, in San Mateo on Dec. 15, 2025. Photo by Manuel Orbegozo for CalMatters A mental health clinician with a bullet-proof vest is helping change the way a Bay Area city responds to some of its emergency calls. That’s what CalMatters’ Cayla Mihalovich found when she visited the San Mateo Police Department earlier this month to check out a new approach for mental health calls.  The city was one of many that searched for a better way to help people in the throes of a mental health crisis. It participated in a 2021 pilot program from San Mateo County that paired law enforcement officers with mental health clinicians in four cities with the aim of freeing up police officers and avoiding unnecessary confrontations.  Rather than police officers having to decide whether to arrest a person, send them to a hospital for a hold or leave them to their own devices, a paired clinician was deployed to provide additional measures such as safety planning, follow-up calls and community mental health resources.  “I fill in the gaps,” said San Mateo Police Department mental health clinician Briana Fair, who builds relationships with people she calls clients and joins officers on some emergency calls. Known as a “co-responder model,” the pilot appeared to work: Involuntary holds decreased about 17% and it reduced the chances of future mental health calls to 911, according to a new study by Stanford University. By reducing the number of involuntary detentions, researchers also estimated that the cities saved as much as $800,000 a year on health costs. Mariela Ruiz-Angel, director of Alternative Response Initiatives at Georgetown Law’s Center for Innovations in Community Safety: “The idea was never about taking cops out of the equation altogether. The idea was that we don’t have to center them as the main response of 911. We don’t have to make public safety about cops. Public safety is about the appropriate response.” Since the end of the two-year pilot, nearly all of San Mateo County cities have rolled out the co-responder model. Cities that participated in the pilot also found a way to sustain the program, including the police department in the city of San Mateo, which currently employs Fair and another part-time clinician. Read more here. Go behind the scenes of our Prop. 50 voter guide: Our team brought the guide to more readers across the state thanks to newsroom partners. Learn more. Dec. 31 deadline: Your gift will have triple the impact thanks to two matching funds, but the deadline is Dec. 31. Please give now. Other Stories You Should Know Gun suicides in rural California A collection of Jeffrey Butler photographs on a table at his daughter’s home in Douglas City on Dec. 4, 2025. Photo by Salvador Ochoa for CalMatters In rural California — where medical and mental health care can be hard to come by — firearm suicides particularly among older men are rattling communities and families who have been left behind, reports CalMatters’ Ana B. Ibarra. Rural counties in Northern California have some of the country’s highest rates of gun suicides among older adults. In Trinity County, for example, at least eight men 70 and older died from an apparent firearm suicide between 2020 and 2024. Over the course of 15 years, the gun suicide rate of adults in this age group in seven northern counties, including Trinity, was more than triple the statewide rate.  In addition to owning more guns, residents in these areas have more limited access to medical and mental health services. When these services are farther away, people often remain in pain for longer because of missed or delayed appointments. In California, more than half of people 70 and over who died by gun suicide had a contributing physical health problem, and over a quarter had a diagnosed mental health condition. Jake Ritter, on the death of his 81-year-old grandfather, Jeffrey Butler, who had health and pain issues and died in Trinity County in 2024 from a self-inflicted gunshot: “I’m sad that he didn’t get the help that he needed, and I’m sad that he felt so strongly that this is the road that he chose.” Read more here. New law to prevent sex abuse at schools Students in a classroom in Sacramento on May 11, 2022. Photo by Miguel Gutierrez Jr., CalMatters By July 2026 all California K-12 schools — including private schools — must have protocols in place to help protect schoolchildren from being sexually abused by educators, as directed by a new state law, writes CalMatters’ Carolyn Jones. The law, which goes into effect Jan. 1, requires schools to enact a number of measures to rein in abuse and hold themselves accountable, including training students, teachers and other school staff to recognize signs of sexual grooming and report misconduct.  The law’s most notable provision is the creation of a database that keeps track of teachers credibly accused of abuse. The database will be available to schools so that administrators can use it to vet prospective teachers. The database is intended to curb the practice of schools re-hiring teachers who have resigned from another school after being accused of sexual misconduct. Read more here. And lastly: Power-guzzling data centers An employee works in a Broadcom data center in San Jose on Sept. 5, 2025. Photo by Brittany Hosea-Small, Reuters A recent report finds electricity use and carbon emissions from California data centers nearly doubled in recent years, with water use climbing even more. CalMatters’ Alejandro Lazo and video strategy director Robert Meeks have a video segment on the environmental report as part of our partnership with PBS SoCal. Watch it here. SoCalMatters airs at 5:58 p.m. weekdays on PBS SoCal. California Voices CalMatters contributor Jim Newton: Despite making gains on her promise to reduce Los Angeles’ homelessness population, Mayor Karen Bass battles a difficult perception problem. California’s elected leaders must oppose the Trump administration’s plans to expand oil and gas drilling on the state’s public lands, writes Ashley McClure, East Bay physician and co-founder of Climate Health Now. Reader reaction: CARE Court can produce positive results in some cases, but it should not be treated as an automatic path to LPS conservatorship, writes Tom Scott, executive director of the California State Association of Public Administrators, Public Guardians and Public Conservators. Other things worth your time: Some stories may require a subscription to read. State attorneys general sue Trump administration over efforts to shutter CFPB // Politico Why cities spend your tax dollars on lobbyists // The Sacramento Bee  CA’s homeless ‘purgatory’ leaves thousands on a waitlist to nowhere // The San Francisco Standard How Trump broke CA’s grip on the auto market // Politico Central Valley surpassed all of CA in job losses this year // The Fresno Bee How private investors stand to profit from billions in LA County sex abuse settlements // Los Angeles Times San Diego just fast-tracked new fire-safety rules for homes // The San Diego Union-Tribune Chronic illness and longing define life in the Tijuana River valley // inewsource

Faulty Genes Don't Always Lead To Vision Loss, Blindness

By Dennis Thompson HealthDay ReporterTUESDAY, Dec. 23, 2025 (HealthDay News) — Genetics aren’t necessarily destiny for those with mutations thought...

By Dennis Thompson HealthDay ReporterTUESDAY, Dec. 23, 2025 (HealthDay News) — Genetics aren’t necessarily destiny for those with mutations thought to always cause inherited blindness, a new study says.Fewer than 30% of people with these genetic variants wind up blind, even though the faulty genes had been thought to cause blindness in 100% of those with them, according to findings published Dec. 22 in the American Journal of Human Genetics.The results could shake up a central belief in genetics, that faulty genes always lead to rare inherited disorders. These disorders are called Mendelian diseases, named after the famed genetics researcher Gregor Mendel.“These findings are striking and suggest that the traditional paradigm of Mendelian diseases needs to be updated,” senior researcher Dr. Eric Pierce, director of the Ocular Genomics Institute at Mass Eye and Ear in Boston, said in a news release.The study focused on inherited retinal degenerations (IRDs), a group of genetic diseases that lead to progressive vision loss and eventual blindness. They cause the light-sensing cells along the back wall of the eye to break down and die off.For the study, researchers created a list of 167 variants in 33 genes that have been previously linked to IRDs.The team then screened nearly 318,000 people participating in a National Institutes of Health research program for the presence of those variants, and found 481 with IRD-causing genetics.However, only 28% of those people had suffered any form of retinal disease or vision loss, and just 9% had a formal IRD diagnosis, results showed.The team double-checked their work by using data on about 100,000 participants in another large-scale study, the UK Biobank.Again, only 16% to 28% of people with IRD-linked genetics had suffered definite or possible signs of vision loss or retinal damage, researchers said.The results suggest that something else is happening alongside a person’s genetic risk to make them wind up with IRD, including environmental factors or other faulty genes, researchers said.“We think these findings are important for understanding IRDs and other inherited diseases,” researcher Dr. Elizabeth Rossin, an investigator at Mass Eye and Ear, said in a news release.“We look forward to finding modifiers of disease and using that new knowledge to improve care for patients with IRDs and potentially other inherited eye disorders,” Rossin said.Future studies will examine other Mendelian disorders, and look for other genetic and environmental factors that could cause these diseases.“The large number of individuals that do not develop an IRD despite having a compatible genotype provide an opportunity to design well-powered research studies to discover disease modifiers, which could spur development of novel therapies,” lead researcher Dr. Kirill Zaslavsky said in a news release. Zaslavsky performed this research during an Inherited Retinal Disorders fellowship at Mass Eye and Ear.SOURCE: Mass General Brigham, news release, Dec. 22, 2025What This Means For YouPeople with genetics linked to vision loss and blindness might be able to ward off these problems, if researchers figure out what’s behind the diseases.Copyright © 2025 HealthDay. All rights reserved.

As oil and gas companies pivot to plastic, California neighborhoods become sacrifice zones again

As oil and gas companies pivot to plastic, certain California neighborhoods become unhealthy sacrifice zones again.

Guest Commentary written by Veronica Herrera Veronica Herrera is a professor of urban planning at UCLA Daniel Coffee Daniel Coffee is a researcher at UCLA’s Luskin Center for Innovation The fossil fuel industry is pivoting. As demand for gasoline declines, oil and gas companies are betting their future on plastic. What once powered our cars is now being refined, cracked and polymerized into bottles, packaging and single-use products that will outlive us all. This shift isn’t just a climate concern — it’s a public health crisis. Plastics are fossil fuels in another form. And the communities most exposed to their production bear the highest health burdens. A new report from the UCLA Luskin Center for Innovation on what defines a plastic-burdened community traces how this expanding plastic economy maps directly onto California’s oil and gas footprint.  Even as California celebrates its climate leadership, our neighborhoods remain entwined with the legacies of fossil fuel infrastructure. More than 2.5 million Californians live within a kilometer of an active or idle oil or gas well. There are pumpjacks in Inglewood, refineries along the Wilmington corridor and wells beside schools in Kern County.  Refinery infrastructure — much of it feeding plastic precursor production — also is heavily concentrated in Los Angeles County, the most populous region in the state. Unequal exposure The science is unequivocal: living near oil and gas development is linked to a wide array of health harms: respiratory disease, cardiovascular illness, adverse birth outcomes and elevated cancer risk. The higher odds for these conditions persist even when controlling for socioeconomic and environmental factors.  In California and beyond, research shows pollutants from drilling and refining — such as volatile organic compounds, nitrogen oxides, particulate matter and formaldehyde — degrade air quality and increase asthma, heart attack and low-birth-weight rates. The burden of these exposures falls unevenly, our analysis shows.  Neighborhoods closest to wells and refineries have far higher proportions of Latino and Black residents, lower incomes and greater health vulnerabilities. On average, for each refinery within 1.5 miles of a community, the median household income is nearly $11,000 lower, poverty rates are 5.5% higher and emergency-room visits for asthma and heart disease are significantly elevated.  The environmental injustices of the oil age are being repackaged in the plastic economy. Globally, the Organisation for Economic Co-operation and Development projects plastic production will triple by 2060. Petrochemicals already account for roughly 14% of oil use and by mid-century could drive nearly half of global oil demand. In other words, even as we transition away from burning fossil fuels, we are locking ourselves into new forms of dependence — embedded in the packaging we discard daily. Recognizing this link is critical as California prepares to implement the Plastic Pollution Mitigation Fund under Senate Bill 54, a plastics recycling and pollution prevention law signed in 2022. The fund will direct hundreds of millions of dollars from the plastics industry to communities harmed by pollution.  Administered wisely, the fund could be a catalyst for mitigating the adverse health impacts of plastics and could create a transformative shift away from plastic production, use and disposability, building on the plastic reduction efforts required of the industry under SB 54. Plastic pollution is not just about littered beaches or overflowing landfills; it begins long before a product reaches a store shelf.  If California truly intends to lead on climate and environmental justice, it must see plastic for what it is — the fossil fuel industry’s new frontier — and it must ensure that communities long treated as sacrifice zones become the first to benefit from solutions.

Interoception Is Our Sixth Sense, and It May Be Key to Mental Health

Disruptions in interoception may underlie anxiety, eating disorders, and other mental health ailments

By the time Maggie May, an Arkansas resident in her 30s, was admitted to a psychiatric clinic in 2024, she had been struggling for years with atypical anorexia nervosa, an eating disorder that leads to severe food restriction and profound disturbances in body image. (Her name has been changed for privacy.) She had already tried traditional interventions with a psychotherapist and a dietitian, but they had failed to improve her condition. So when May heard about a trial of a new and unconventional therapy, she jumped at the opportunity.The treatment was unusual in that alongside talk therapy, May underwent several sessions in a sensory-deprivation chamber: a dark, soundproof room where she floated in a shallow pool of water heated to match the temperature of her skin and saturated with Epsom salts to make her more buoyant. The goal was to blunt May’s external senses, enabling her to feel from within—focusing on the steady thudding of her heart, the gentle flow of air in and out of her lungs, and other internal bodily signals.The ability to connect with the body’s inner signals is called interoception. Some people are better at it than others, and one’s aptitude for it may change. Life events can also bolster or damage a person’s interoceptive skills. Sahib Khalsa, a psychiatrist and neuroscientist at the University of California, Los Angeles, and his colleagues think a disrupted interoception system might be one of the driving forces behind anorexia nervosa. So they decided to repurpose a decades-old therapy called flotation-REST (for “reduced environmental stimulation therapy”) and launched a trial with it in 2018. They hypothesized that in people with anorexia and some other disorders, an underreliance on internal signals may lead to an overreliance on external ones, such as how one looks in the mirror, that ultimately causes distorted body image, one of the key factors underlying these conditions. “When they’re in the float environment, they experience internal signals more strongly,” Khalsa says. “And having that experience may then confer a different understanding of the brain-body relationship that they have.”On supporting science journalismIf you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.Studies have implicated problems with this inner sense in a wide variety of conditions, including anxiety disorders, post-traumatic stress disorder and borderline personality disorder. Some researchers and clinicians now think that problems in interoception might contribute to many mental illnesses. Alongside this research, which itself is complicated by challenges in testing design and by a less than clear understanding of interoception, other groups are also developing therapies that aim to target this inner sense and boost psychological well-being.This work is circling in on a central message: the body and mind are inextricably intertwined. “We have always thought about [mental health conditions] as being in the brain or the mind,” says Camilla Nord, a professor of cognitive neuroscience at the University of Cambridge. But clinicians have long noted that people with mental illness frequently report physical symptoms such as abnormalities in heartbeats, breathing and appetite, she adds.The idea that the body can influence the mind dates back centuries. In the 1800s two psychologists on opposite ends of the globe independently proposed a then novel idea: emotions are the result of bodily reactions to a specific event. Called the James-Lange theory after its founders, American psychologist William James and Danish doctor Carl Lange, this view ran counter to the long-dominant belief that emotions were the cause, not a consequence, of corresponding physiological changes.Although this notion has garnered critics, it inspired a slew of studies. The 1980s saw a surge of interest in the role of physiological signals in panic disorders. Researchers discovered that they could bring on panic attacks by asking people to inhale carbon dioxide–enriched air, which can increase breathing rates, or by injecting them with isoproterenol, a drug that increases heart rate.Breathing rate can affect how someone perceives the intensity and unpleasantness of pain.These findings led some psychologists to suggest that physical sensations were the primary trigger of panic attacks. In the early 1990s Anke Ehlers, a psychologist then at the University of Göttingen in Germany, and her team examined dozens of people with panic disorders and reported that these patients were better able to perceive their heartbeats than healthy individuals—and that this greater awareness was linked to more severe symptoms. On top of that, a small, preliminary study by Ehlers of 17 patients revealed that those who were more skilled at this task were more likely to relapse and start having panic attacks again. These observations hinted at a two-way dynamic: not only could physical sensations within the body cause psychological effects, but the ability to perceive and interpret those signals—in other words, one’s interoceptive ability—could have a profound influence on mental health.Over the years a growing body of evidence has indicated that interoception plays an important role in shaping both emotions and psychological health. A large chunk of this work has focused on the heart. With every heartbeat, blood rushes into the arteries and triggers sensors known as baroreceptors, which shoot off messages to the brain conveying information about how strongly and rapidly the heart is beating.In one pivotal 2014 study, Hugo Critchley, a neuropsychiatrist at Brighton and Sussex Medical School in England, and his team reported that this process can affect a person’s sensitivity to fear. By monitoring volunteers’ heartbeats while they viewed fearful or neutral faces, they found that people detected fearful faces more easily and judged them as more intense when their heart was pumping out blood than when it was relaxing and refilling. But participants with higher levels of anxiety often perceived fear even when their hearts relaxed.Researchers have also demonstrated that bodily signals such as breathing patterns and gut rhythms can influence emotional reactions. People are quicker to react to fearful faces while breathing in than while breathing out, and breathing rate can affect how someone perceives the intensity and unpleasantness of pain.In more recent work, some neuroscientists have turned their attention to the gastrointestinal system. In 2021 Nord and her colleagues discovered that people given a dose of an antinausea drug that affects gut rhythms—processes within the stomach that help digestion—were less likely to look away from pictures of feces than they normally would have been. These disgust-related visceral signals, Nord speculates, may be relevant to eating disorders. “It’s possible that some of these signals contribute to feeling aversion to signals of satiety, making satiety very uncomfortable, a feeling you don’t want to feel,” she says.But how, exactly, do disruptions in interoception come about? Many researchers suspect it may have to do with our brain’s predictions going awry. Interoception, like our other senses, feeds information to the brain, which some neuroscientists suggest is a prediction machine: it constantly uses our prior knowledge of the world to make inferences about incoming signals. In the case of interoception, the brain attempts to decode the cause of internal sensations. If its interpretations are incorrect, they may lead to negative psychological effects—for example, if a person erroneously assumes their heart rate is elevated, they may begin to feel anxious in the absence of a threat. And if a person has learned to associate pangs of hunger with disgust, they might severely restrict how much food they consume.Inner signals can be much more ambiguous than the external input from other senses such as sight and hearing. So the brain’s prior information about these internal signals becomes especially important, says André Schulz, a professor of psychology at the University of Luxembourg.To better understand and assess potential mismatches in subjective and objective measures of our bodily signals, researchers have developed a framework that captures the different dimensions in which interoceptive processing occurs. In 2015 Sarah Garfinkel, then a postdoctoral researcher in Critchley’s group at Brighton and Sussex, and her colleagues proposed a model to clearly differentiate three categories of interoceptive processing: interoceptive accuracy (how well someone performs, objectively, on relevant tasks such as heartbeat detection), interoceptive sensibility (a person’s subjective evaluation of their interoceptive abilities), and interoceptive awareness (how well that self-assessment matches their actual abilities).Along with their collaborators, Garfinkel, now at University College London, and Critchley have found that in autistic adults there is a link between anxiety and a poor ability to predict one’s interoceptive skill—in this case, one’s sensitivity to heartbeat. In a study of 40 people (20 of whom had autism), they and their colleagues discovered that individuals with autism performed worse on a heartbeat-detection task and were more likely to overestimate their interoceptive abilities than those without autism. This disconnect was more pronounced in people with higher levels of anxiety, suggesting that errors in the ability to predict bodily signals may contribute to feelings of anxiety, Critchley says.In recent years the list of psychiatric conditions linked to interoceptive dysfunctions has grown. Some, such as panic and anxiety disorders, are associated with heightened attention to one’s internal processes; others, such as borderline personality disorder and schizophrenia, may be tied to a blunting of one’s ability to connect with these signals. In a review of interoception research, published in 2021, Nord and her colleagues examined 33 studies that collectively involved more than 1,200 participants. They found that people with a range of psychiatric disorders, including anxiety disorders and schizophrenia, shared similar alterations in the insula, a key brain region linked with interoception during body-sensing-related tasks.Overall, though, studies show mixed results. “If you look across the literature, [however many] studies have found an association with, say, anxiety, [a roughly] equal amount will have not found a relationship or found it in the other direction,” says Jennifer Murphy, a psychologist at the University of Surrey in England.The varying results could stem from the challenges associated with studying interoception, which can be difficult to both manipulate and measure. Take cardiac interoception. In most early studies in this domain, participants counted their pulses, but this test may measure people’s estimate of their heart rate rather than how well they can feel their heartbeat. This flaw was perhaps most clearly demonstrated in a 1999 study in which people with pacemakers reported their heart rates while experimenters (with the participants’ consent) secretly tuned their pacemakers’ timing up or down. Participants’ self-reported heart rates didn’t follow the shifts in the actual pulses; their beliefs about how their heart rates should be changing had a much stronger influence.To address these limitations, scientists have been devising better study methods. Micah Allen, a neuroscientist at Aarhus University in Denmark, and his team have developed a heart-rate-discrimination task in which people are asked to report whether a series of tones is faster or slower than their current pulse, allowing researchers to quantify how sensitive an individual is to their heartbeats. Allen and his colleagues are now testing breath interoception in a similar way. Using a computer-controlled device, the researchers can make precise changes to the air resistance someone feels when they inhale through a tube. By doing so, they can quantify how well the person can detect changes in their breathing.Using these new techniques, Allen’s team has learned that an individual’s interoceptive chops don’t translate across all domains. In a recent preprint study of 241 people, they found that a person’s ability to perceive their heart rate wasn’t correlated to their performance in a breathing-resistance task.Researchers have also been combining these behavioral tests with measurements of brain activity. One example is the heartbeat-evoked potential, a spike in brain signaling that occurs each time the heart beats. Scientists have found that changes in these signals, which can be detected with noninvasive brain-imaging techniques such as electroencephalography, are linked to accuracy in heartbeat-detection tasks and to the ability to process emotions. Similar brain signals related to organs such as the gut and those of the respiratory system have been linked to the ability to perceive sensations within those organs.These studies indicate that interoception abilities don’t align across a person’s bodily functions, from breathing to heart rate to gut rhythms. It’s therefore difficult to know whether the conflicting findings about the role of interoception disruptions in mental disorders mean there is no meaningful relation to be found or whether the issue is that researchers have simply not been using the right task or studying the most relevant system or level of interoception, Murphy says. “It’s very unlikely that every condition will have the same bit of interoception disrupted.”Untangling how, exactly, interoception is disrupted in people with mental illness remains an active area of investigation. Some experts say answers may come from treatment trials investigating whether interventions that target disturbances in this inner sense might boost mental health. Many such studies are currently underway.“To understand what interoception is, we need to manipulate it,” Allen says. “And to understand its role as a biomarker, as something that is related to mental health, we also need to manipulate it.”Jane Green knows stressful situations can have immediate effects on her body. For Green, who has autism, reading a piece of bad news or dealing with a face-to-face confrontation may set off a chain reaction in her body: a rush of adrenaline followed by a pounding heart, bloating and itchiness, among other physical reactions.Such responses may be linked to an inability to read one’s inner body. In 2019 she took part in a clinical trial in which Critchley, Garfinkel and their colleagues sought to test just that—how resolving a discrepancy between a person’s perceived interoceptive abilities and reality could improve anxiety levels in adults with autism spectrum disorder. The intervention in the study focused on tasks that involved heartbeat detection.After training and testing 121 participants (half of whom were randomly assigned to receive a noninteroception-based control task) across six sessions, the team reported in a 2021 paper that this treatment successfully reduced anxiety in their participants and that this effect persisted for at least three months.Participating in the trial was a “real turning point” in Green’s ability to deal with anxiety, she says. “I recognize now that when I’m stressed, whether I like it or not, my body reacts,” she explains. Although she still experiences physical reactions to emotionally charged situations, they are often less severe than they were prior to the treatment. And her knowledge of what’s happening in her body has made it easier to cope, she adds. Green is chair and founder of SEDSConnective, a charity dedicated to neurodivergent people with connective tissue disorders such as Ehlers-Danlos syndromes. These conditions tend to overlap with anxiety disorders, and Green is now advocating for interoception-based therapies to help affected people.A person’s interoceptive capabilities might be especially malleable during early childhood or adolescence.For May, who participated in the flotation-REST trial, what she learned from being cut off from the external world helped her to get through an inpatient stay at an eating-disorder clinic where she was being forced to eat—and, as a result, gain weight. “You’re working on the things that drove you to come in the first place, but at the same time, your distress with your body is getting worse and worse,” she says. When she was in the flotation chamber, however, May’s awareness of her physical body would slip away, reducing some of the negative feelings she had about herself and quieting the worries that swirled in her mind. “You can’t tell where your body stops and the water begins,” May says. “Because you’re completely buoyant, you also have no sense of the ways that your body distresses you.”Flotation-REST shows promise: in a clinical trial of 68 people hospitalized for anorexia nervosa who were randomly assigned to the therapy or a placebo, Khalsa’s team found that six months after treatment, those who received therapy reported less body dissatisfaction than those who did not. The researchers have also created a version of this therapy for anxiety and depression. In early-stage clinical trials, this intervention appeared to reduce the symptoms of those disorders. Now they are investigating whether this therapy might also benefit people with amphetamine use disorder.Other interoception-based treatments are also under investigation. At Emory University, a group led by clinical psychologist Negar Fani has been examining the effects of combining a mindfulness-based intervention with a wearable device that delivers vibrations corresponding to a person’s breaths. In a group of trauma-exposed individuals, this intervention increased the participants’ confidence in their bodily signals more than the mindfulness-based intervention alone. Even long after these sessions, people report being able to recall the feeling of breath-synced vibrations, Fani says. “It helps to ground them, brings them back into the present moment. They can access their body signals and figure out what they want to do with them.” The team is now conducting a follow-up study to see whether this treatment can improve mental well-being in people who have experienced trauma.In yet another ongoing trial, Nord is collaborating with Garfinkel on a series of studies aimed at understanding in which body systems—and in which of the three dimensions (accuracy, sensibility and awareness)—interoception is altered in people with various mental disorders, among them anxiety and depression. As part of that effort, the researchers are testing interventions, including interoceptive training, mindfulness therapy—to help improve the mind-body connection—and stimulation of the insula with focused ultrasound.Scientists still have plenty of questions to answer about interoception. One major open question is how differences in interoception arise. Some of our interoceptive abilities may begin taking shape during early infanthood. Scientists have discovered that babies as young as three months show differences in the amount of time they spend looking at colored shapes moving either in or out of sync with their heartbeats—a finding that suggests our ability to sense heart rhythms is present at this young age.Interactions with caregivers during one’s first years may play a crucial role in determining how in tune a person becomes with their body. The way a parent responds to an infant’s cues about being hungry, tired or in pain, for instance, may shape how well the child is able to interpret those signals later in life. Although direct evidence for this hypothesis is still lacking, studies have shown that an individual’s early caregiving environment can shape how their body responds to stress.Other factors such as a person’s sex or various environmental conditions, including adversity in early life, may also influence how interoception develops. Some research suggests that adverse experiences, especially chronic, interpersonal trauma early in life, may be key contributors. Clinicians have long observed that traumatic events can lead people to detach or “dissociate” from the body, and some researchers have proposed that this disconnect can disrupt interoceptive processes over time. For a subset of people, these alterations might be linked to an increased likelihood of self-harm and suicide: one 2020 study, for example, found that people with a history of suicide attempts and a diagnosed mental illness, such as anxiety, PTSD or depression, were worse at an interoceptive heartbeat-detection task than those who had the same ailments but had not attempted to take their own life.A person’s interoceptive abilities may change over time. Interoceptive capabilities might be especially malleable during certain life stages: periods such as early childhood, when a person is just learning how to interpret their bodily signals, or adolescence, when puberty is creating a whirlwind of physical changes. It might be one mechanism, among many, that explains why “these times tend to be risk periods for the development of mental illness,” Murphy says.The boundaries of interoception are also only beginning to be understood. In recent years some scientists have become interested in probing the links between the immune system and the brain, which are in constant conversation. An emerging body of work suggests that the brain both keeps tabs on and influences what happens in the immune system, and the immune system can in turn affect the brain. Studies have linked dysfunction in the immune system—namely, inflammation—to mental illnesses such as depression, psychosis and trauma-related disorders. The immune system may affect our mental states over much longer time scales than, say, the heart, which can influence our emotional experiences in real time.Understanding the mysteries of interoception may lead to better therapies for illnesses of the mind—and the body. Some researchers believe that understanding interoception may ultimately be helpful for treating physical symptoms as well. Schulz and his team, for instance, are currently evaluating interoception-based treatments for chronic fatigue syndrome (also known as myalgic encephalomyelitis), a complicated disorder that causes a range of symptoms, including severe tiredness. “Interoception has so much relevance to health in general,” Fani says. “We can’t ignore it anymore.”IF YOU NEED HELPIf you or someone you know is struggling or having thoughts of suicide, help is available. Call or text the 988 Suicide & Crisis Lifeline at 988 or use the online Lifeline Chat at chat.988lifeline.org.

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